Assessment of tissue damage due to percutaneous nephrolithotomy using serum concentrations of inflammatory mediators.

Abstract Objectives To determine the percutaneous nephrolithotomy (PCNL) effects on the tissues using the quantification of inflammatory mediators, and to assess their impact on the development of postoperative complications. Patients and methods Prospective observational non-randomized study on 40 patients who underwent to PCNL. 50 patients with kidney stone who were treated by extracorporeal shock wave lithotripsy (ESWL) were used as control group. Interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) were determined at baseline (T0: before treatment), and after 2, 6 and 24 h (T1, T2 and T3). Results No relevant changes on IL-1β and TNF-α were found. IL-6 showed two peaks at 2 and 6 h post-PCNL (median 17.8 and 15.8 pg/mL, respectively). At 24 h CRP had reached its peak value (3.4 mg/L). The group treated with ESWL showed no significant changes in any of the markers. The serum concentration of IL-6 and CRP at 24-h post-NLP is different depending on the occurrence of complications ( p  = 0.001 and p  = 0.039, respectively). IL-6 showed a good predictive power for the development of complications (AUC .801). Conclusions Tissue damage caused by the PCNL is low. This damage increases significantly in those cases showing postoperative complications. IL-6 at 24 h has been shown to be a good predictive tool for the development of complications.