Linear Darier Disease

Darier disease is an autosomal dominant genodermatosis that usually appears between the ages of 10 and 20 years in seborrheic areas of the trunk and face; it can sometimes present a localized, linear, or zosteriform pattern. The presence of these patterns leads to controversy about the most suitable name, as some authors consider it a variant of Darier disease and others consider it an epidermal nevus with special histologic features. We present 2 cases of linear Darier disease seen in our department. The first case was that of a 42-year-old man with no relevant personal or family history, who had had skin lesions located on the right chest for 25 years. The lesions had remained stable since onset and were asymptomatic, except with exercise, during which the erythema and pruritus increased. The second case was that of a 51-yearold man who was positive for human immunodeficiency virus category A3 and for 17 years had had slightly pruritic skin lesions located on the right abdomen; these lesions had become more apparent in recent months. In both patients we observed several grouped, round papules smaller than 5 mm that were erythematous-orange in color, keratotic, slightly infiltrated, and in some cases excoriated. The lesions had a metameric distribution in the right clavicular fossa and right subpectoral region in case 1 (Figure 1) and on the right abdomen in case 2 (Figure 2). No skin lesions in other areas or mucosal or nail lesions were observed in either of the 2 patients. diseminada como presentacion inicial de criptococosis sistemica en un paciente con artritis reumatoide. Actas Dermosifiliogr. 2010;101:274-5. 6. Korfel A, Menssen HD, Schwartz S, Thiel E. Cryptococcosis in Hodgkin’s disease: description of two cases and review of literature. Ann Hemat. 1998;76:283-6. 7. Ramos L, Lopez C, Gomez C, Mathurin S, Mateo A. Cutaneous cryptococcosis in a patient with systemic erythematous lupus. Mycoses. 2001;44:419-21. 8. Jones-Caballero M, Fernandez-Herrera J, Fernandez-Pena P, Fraga-Fernandez J, Garcia-Diez A. Criptococosis cutanea imitando a Molluscum contagiosum en paciente con SIDA. Actas Dermosifiliogr. 1992;1:24-6. 9. Massa MC, Doyle JA. Cutaneous cryptococcosis simulating pyoderma gangrenosum. J Am Acad Dermatol. 1981;5:32-6. 10. Hecker M, Weinberg JM. Cutaneous cryptococcosis mimicking keloid. Dermatology. 2001;202:78-9. M.T. Bordel-Gomez,a,* M.I. Zafra-Cobo,a M.E. Cardenoso-Alvarez,a J. Sanchez-Estella,a M.I. Martin-Arribasb