Serum SAA1 and APOE are novel indicators for human cytomegalovirus infection

Human cytomegalovirus (HCMV) infection is a global concern and highly infectious. HCMV-infected individuals are often carriers with damaged immunity. However few diagnostic indicators block HMCV control and prevention. Thus, we measured 21 serum proteins related to HCMV infection using iTRAQ-labeling based quantitative proteomic approaches and SAA1 and APOE were confirmed as candidate serum indicators for identification of HMCV infection according to ROC curve analysis and that co-occurrence of SAA1 and APOE are better markers than individual proteins.