Use of peripheral blood mRNA signature to distinguish patients with breast cancer from benign breast disease and nonconclusive mammography.
2010
10581 Background: Due to small volume and high-density breast, Asian women, especially the young group, are classified as BI-RADS 0 in their mammographic diagnosis when imaging cannot identify. Within the framework of Breast Cancer Screening Program of Fudan University Cancer Hospital (FUCH), this proportion is at least 10%. Follow-up is usually recommended, which requires a long, expensive and anxiety producing process, based on ultrasonography or MRI or even biopsy. No alternative based on blood biomarkers has yet succeeded to discriminate within the BI-RADS 0 patients, between breast cancer (BC) and benign breast disease (BBD). DNA-microarrays and PAXgene are used in the present study to explore gene expression repertoire in peripheral blood samples, with attractive perspectives for new biomarker discovery. Methods: 84 BC and 94 BBD patients with mammographic results and confirmed pathologic information were enrolled in our study, categorized in two groups, 79 BC + 73 BBD with BI-RADS 1-5, and 5 BC + 2...
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