Left ventricular function in Duchenne muscular relation to some clinical parameters

Duchenne muscular dystrophy (DMD) is a severe X loss of dystrophin in skeletal and cardiac muscle. The aim of the study was to evaluate cardiac involvement in DMD patients and to ventilatory function and muscle strength. Forty five male, verified DMD patients at mean age of 11,5±4, 3 years, underwent examination, ECG and transthoracic еchocardiography. Forced vital capacity and forced expiratory volume in 1 s were assessed. assessment score and Medical Research Council grading method were used for muscle strength and functional disability evaluation. systolic (LV) dysfunction was found in 24,4% of the patients and some impairm ent in diastolic function in 53. 3%. The earliest finding was decreased early diastolic myocardial velocities at lateral mitral annulus, registered in patients 10 years of age. A positive correlation was found between muscle weakness parameters and ventilatory function the indices of LV function. LV dysfunction was a common finding in DMD and its prevalence and severity increased with age. The parallel decrease in peripheral, respiratory and cardiac muscle function confirmed the common pathological molecular mechanis m of muscle impairment.