Clinical research for treatment of brain metastases of lunch cancer

OBJECTIVE:To study the therapeutic effects of brain metastases from lung cancer by radiotherapy combined with chemotherapy and raidothrapy alone. METHODS: Sixty cases with brain metastases from lung cancer were randomly divided into 2 groups (30 cases in each group), including a simple irradiation group receiving whole brain irradiation to a total dose of 40 Gy, and a combined group receiving the same radiotherapy plus Vm-26. RESULTS: The effective rate of combined group (83.3%) was not significantly higher than that of simply irradiation group (80.0%).The middle-survival was 5.4 months in irradiation group and 7.6 months in combined group respectively,with significant difference,Z=2.365,P=0.018 0.The side effects including gastrointestinal tract reaction and myelosuppression in combined group was higher than those in irradiation group.But almost all the patients can tolerate the side effects. CONCLUSION: The patients suffered from brain metastases from lung cancer can prolong the survival time by radiotherapy combined with chemotherapy.