Risk Factors for Adverse Kidney Disease Outcomes in Type 1 Diabetes (T1D)

Diabetic kidney disease (DKD) is a major complication of T1D. To better understand the risks of developing DKD, we evaluated risk factors in participants from the T1D Exchange registry who completed 5-year follow-up. Participants had at least two eGFR and albuminuria measurements recorded during the 5 year period; also T1D duration ≥1 year, age ≥10 years, eGFR ≥60 ml/minute and no documented albuminuria at enrollment. Adverse kidney outcomes were defined as eGFR Disclosure J.B. McGill: Research Support; Self; AstraZeneca. Consultant; Self; Boehringer Ingelheim GmbH. Speaker9s Bureau; Self; Aegerion Pharmaceuticals. Consultant; Self; Bayer AG, Dexcom, Inc., Intarcia Therapeutics, Inc.. Speaker9s Bureau; Self; Janssen Pharmaceuticals, Inc., MannKind Corporation. Research Support; Self; Novartis Pharmaceuticals Corporation. Consultant; Self; Novo Nordisk A/S. M. Wu: None. R. Pop-Busui: Research Support; Self; AstraZeneca. K.R. Mizokami-Stout: None. W.V. Tamborlane: Consultant; Self; AstraZeneca, Boehringer Ingelheim GmbH, Eli Lilly and Company, Medtronic MiniMed, Inc., Novo Nordisk Inc., Sanofi, Takeda Pharmaceuticals U.S.A., Inc. G. Aleppo: Research Support; Self; AstraZeneca, Novo Nordisk Inc.. Consultant; Self; Dexcom, Inc.. Advisory Panel; Self; Novo Nordisk Inc.. R. Gubitosi-Klug: None. M.J. Haller: None. S.M. Willi: Advisory Panel; Self; Boehringer Ingelheim GmbH. Other Relationship; Self; Caladrius Biosciences, Inc.. Consultant; Self; GlaxoSmithKline plc., JAEB Center For Health Research. N.C. Foster: None. C. Zimmerman: None. I. Libman: Consultant; Self; Novo Nordisk A/S. S. Polsky: Research Support; Self; Dexcom, Inc.. Other Relationship; Self; T1D Exchange. Research Support; Self; National Institute of Diabetes and Digestive and Kidney Diseases. M.R. Rickels: Consultant; Self; Hua Medicine, Xeris Pharmaceuticals, Inc..