두경부 영역의 악성 림프종

Background and Objectives：There are considerable geographic and ethnic differences in the incidence, age distribution, and histologic subtypes of lymphoma. There are differences in outcomes of treatment and prognosis according to the stage, age, primary site, serum LDH, and performance status. We performed this study to investigate the outcomes of treatment, prognostic factors, and differences between Hodgkin’s disease (HD) and non-Hodgkin’s lymphoma (NHL). Materials and Method：A retrospective review was made of 84 malignant lymphoma patients involving the head and neck treated between 1993 and 2000 with chemotherapy or combined modality therapy at Hanyang University Hospital. Results：Among 84 patients included in the study, 68 had NHL and 16 had HD. The median age of patients at diagnosis was 55 and 43 for patients of NHL and HD, respectively. Male patients made up 56% of the NHL patients and 75% of the HD patients. The most common extranodal site of NHL was palatine tonsil (16.2%). The most common histologic subtype was diffuse large cell lymphoma (64.7%) in NHL and mixed cellularity (43.8%) in HD. The useful prognostic factors predicting overall survival were stage, histologic subtype, serum LDH, and performance status for NHL, and age for HD. Conclusion：Although the characteristics of malignant lymphoma in Korea differed from those in the western countries, International Prognostic Index (IPI) still proved useful