Long-term changes in graft height after sinus floor augmentation with mesenchymal stem cells in a randomised clinical trial: radiographic evaluation with a minimum followup of 2.5 years
2012
To compare the changes in graft height in patients after sinus floor augmentation (SFA) with and
without mesenchymal stem cells (MSCs) and to evaluate the survival rate of implants placed after SFA.
Material and methods: Twenty patients were randomised into two groups. The test group patients had a
bone biopsy taken from the tuberosity region from which bone cells were cultured. All patients had a
SFA with a composite bone graft (BioOss®/autogenous bone). The patients in the test group had the
cultured cells added. Two implants were placed in the augmented area four months later and the
augmentation height at the distal side of the implants was evaluated from panoramic radiographs at the
time of implant placement (T1) and after a minimum of 2.5 years (T2). The implant survival was
evaluated. Due to insufficient bone quality one implant could not be placed 4 months after SFA, two
implants disintegrated after prosthetic treatment and two implants in one patient were unaccounted for
since the patient failed to show up â all in the MSC group. A statistically significant reduction in
augmentation height of 1.27 ± 0.23 mm and 1.88 ± 0.37 mm in the MSC and non-MSC group was found
after a minimum of 2.5 years, respectively (p
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