Evaluation of effectiveness of the use of toothpastes in treatment of non-carious teeth diseases

Aim. To assess the effectiveness of the use of therapeutic and prophylactic toothpastes containing hydroxyapatite nanoparticles or sodium fluoride in patients with non-carious lesions. Methods. Mixed saliva was studied in 40 individuals. All subjects were divided into three groups. Group 1 (n=15) used toothpaste №1 containing zinc citrate and sodium fluoride for tooth brushing, group 2 (n=15) brushed teeth with a paste №2 with hydroxyapatite nanoparticles which contained materials removing dental plaque due to antioxidant β-glycyrrhetinic acid possessing anti-inflammatory activity. The control group included 10 subjects with healthy oral cavity. Hyperesthesia of teeth was assessed using Shiff air sensitivity scale, indices of prevalence of tooth hyperesthesia and intensity of tooth hyperesthesia in %, periodontal condition (papillary marginal alveolar index) in % and the oral hygiene score were determined. The activity of lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase (U/l) before and after tooth brushing with toothpastes containing hydroxyapatite particles or sodium fluoride, was also measured. Results. After tooth brushing with both pastes for three months, a decrease of tooth hyperesthesia was observed, as evidenced by the values of Shiff test, index of prevalence of hyperesthesia and intensity of tooth hyperesthesia. Oral hygiene and periodontal state improved. The best effect was observed with a paste №2, containing anti-inflammatory and abrasive components and hydroxyapatite nanoparticles. This is confirmed by a decrease of the activity of lactate dehydrogenase present in anaerobic bacteria, as well as activity of aspartate aminotransferase and alanine aminotransferase, reflecting a decrease of inflammation in the periodontal tissues. Conclusion. Use of toothpastes containing hydroxyapatite nanoparticles or sodium fluoride reduces hyperesthesia of the enamel and inflammation in the periodontium and is accompanied by decreased activity of enzymes in mixed saliva.