Is there a need for preoperative α-blocker in patients missed preoperative diagnosis of extra-adrenal retroperitoneal paraganglioma undergoing paraganglioma resection? A retrospective study of 167 cases at a single center

Introduction : Preoperative α-adrenergic blockade is believed to decrease perioperative risks and mortality in adrenal pheochromocytoma surgeries. The aim of this study is to evaluate the effects of the preoperative α-adrenergic blockade on patients’ outcomes in extra-adrenal retroperitoneal paraganglioma surgeries. Methods:  One hundred and sixty-seven patients diagnosed as extra-adrenal retroperitoneal paraganglioma by postoperative histopathology in the General Hospital of People9s Liberation Army between January 2000 and July 2017 were compared as to the choice of preoperative α-adrenergic blockade with respect to preoperative status, intraoperative and postoperative cardiovascular events, intake and output, length of stay in ICU, length of hospital stay, and short time outcomes. Results: The intraoperative morbidity of heart rate elevation and highest heart rate were higher in patients undergoing tumor manipulation with preoperative α-adrenergic blockade than those without ( P 0.05). There were no significant differences in postoperative complications and outcomes ( P >0.05). Conclusion: Under the current medical techniques, either with or without preoperative medicine, resection of extra-adrenal retroperitoneal paraganglioma could be carried out successfully.