Clinical features of adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia

Adefovir dipivoxil (ADV) is commonly used as an anti-viral agent in the treatment of chronic hepatitis B,with a dose-and time-dependent nephrotoxicity.Clinical analysis was made in 4 patients with chronic hepatitis B who developed Fanconi syndrome and hypophosphatemic osteomalacia after long-term use of ADV (10 mg/d). Key words: Adefovir dipivoxil ;  Fanconi syndrome ;  Hypophosphatemia;  Osteomalacia