Research of transmyocardial stent to treat acute myocardial infarction

Objectives To explore the feasibility, safety and efficacy of transmyocardial stent to treat acute myocardial infarction.Methods 24 Chinese mini swines have been divided into 2 groups randomly:group myocardial infarction（group MI n1=14） and group transmyocardial stent（group ST n2=10）.In group MI, acute myocardial infarction animal model has been established by the ligation of the left descending coronary artery. In group ST, after the establishment of the model, 3 transmyocardial stents were implanted.4 weeks later, echocardiography and pathological analysis have been done.Results The density of blood vessel in group ST is 6.47±0.60/HP which is significantly higher than the group MI. At the same time, left ventricular ejection fraction and regional wall motion score index （WMSI） in group ST are ameliorated significantly compared with group MI.Conclusion It is feasible and safe to implant transmyocardial stents in acute myocardial infarction model. Although the channel can’t remain patent in long term, the prolonged stimulation can cause moderateserious inflammatory reaction and proficient angiogenesis.