FERTILITY PRESERVATION IN A TRANSGENDER MAN WITHOUT PROLONGED DISCONTINUATION OF TESTOSTERONE: A CASE REPORT AND LITERATURE REVIEW

Abstract Objective To study the feasibility of fertility preservation in a transgender male without an extended period of androgen cessation. Design Report of a seminal case of oocyte cryopreservation in a transgender man without stopping testosterone therapy before controlled ovarian stimulation. We performed a literature review, identifying 5 publications on oocyte cryopreservation outcomes in transgender men on testosterone. Setting A university-affiliated fertility clinic in Canada. Patient(s) A 28-year-old transgender man, taking testosterone for 3 years requesting oocyte cryopreservation before gender-affirming surgery. He desired to proceed without stopping testosterone. Pre-treatment AMH was 1.89 ng/mL. The patient’s consent was obtained for written publication. Intervention(s) Testosterone was stopped for only three doses (immediately prior to and during ovarian stimulation. A standard antagonist protocol was used with letrozole, to minimize estrogenic side effects. Main Outcome Measure(s) Number of oocytes retrieved and days off testosterone. Result(s) Thirteen oocytes were retrieved; eleven were mature and vitrified. The total time off testosterone was 24 days. In all prior publications, testosterone was stopped for 3-6 months. Conclusion(s) Transgender men have traditionally discontinued exogenous testosterone until the resumption of menses (up to 6 months). This is known to be distressing. This is the first published case demonstrating the feasibility of ovarian stimulation without prolonged testosterone cessation in a transgender man. Future studies with a larger sample size should be performed to confirm these findings. The short duration off testosterone may improve patient’s experiences, increase treatment acceptability, and decrease gender dysphoria for transgender men considering fertility preservation.