Highly enantioselective α-aminoxylation of aldehydes and ketones in ionic liquids

As the first example for the synthesis of optically active α-hydroxyaldehydes and α-hydroxyketones in ionic liquids, we applied RTILs into l-proline catalyzed direct enantioselective α-aminoxylation of both aldehydes and ketones successfully. This protocol features a number of advantages, such as recycling of green solvents and chiral organocatalyst, high yields, excellent enantioselectivities, short reaction times, and broad substrate scope.