оСобенноСти цитокинового проФиля у детей, больных коклюшем

Comparative analysis of cytokine profile was performed in 149 children aged 1.5 to 14 years, out of which 41 had suffered from pertussis as monoinfection, 53 –in combination with mycoplasma infection, 55 - with acute viral infections. Cytokine profile in patients with pertussis differs in reduction of induced production of proinflammatory cytokines, especially IFN-γ. A key feature of the functioning of the cytokine network in pertussis is the active production of anti-inflammatory cytokines - IL-4 and IL-10 upward the early periods of the disease, that indicates the importance of Th-2-type response in whooping cough.