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Dean Sheppard

University of California, San Francisco
San Francisco General Hospital

410

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35215

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Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis.

2021 The Journal of Pathology
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Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy

2021 Cell Reports
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IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

2021 bioRxiv
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Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

2021 Journal of Clinical Investigation
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Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

2021 Nature Communications
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Cooperation between Cancer Cells and Regulatory T Cells to Promote Immune-escape through Integrin αvβ8-Mediated TGF-β Activation

2021
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αVβ8 integrin targeting to prevent posterior capsular opacification (PCO)

2021 JCI insight
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Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking

2020 Science Advances
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Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.

2020 Nature Cell Biology
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KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice

2020 JCI insight
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