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Kim S. Beyer
Kim S. Beyer
Biology
DOT1L
Transferase
Drug discovery
Binding site
4
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115
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Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach
2017
ACS Medicinal Chemistry Letters
Henrik Möbitz
Rainer Machauer
Philipp Holzer
Andrea Vaupel
Frédéric Stauffer
Christian Ragot
Giorgio Caravatti
Clemens Scheufler
César Fernández
Ulrich Hommel
Ralph Tiedt
Kim S. Beyer
Chao Chen
Hugh Zhu
Christoph Gaul
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Citations (24)
Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach
2016
ACS Medicinal Chemistry Letters
Chao Chen
Hugh Zhu
Frédéric Stauffer
Giorgio Caravatti
Susanne Vollmer
Rainer Machauer
Philipp Holzer
Henrik Möbitz
Clemens Scheufler
Martin Klumpp
Ralph Tiedt
Kim S. Beyer
Keith Calkins
Daniel Guthy
Michael Kiffe
Jeff Zhang
Christoph Gaul
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Citations (34)
Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket.
2016
ACS Medicinal Chemistry Letters
Clemens Scheufler
Henrik Möbitz
Christoph Gaul
Christian Ragot
Celine Be
César Fernández
Kim S. Beyer
Ralph Tiedt
Frédéric Stauffer
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Citations (27)
A comparative study of fragment screening methods on the p38α kinase: new methods, new insights
2011
Journal of Computer-aided Molecular Design
Scott Pollack
Kim S. Beyer
Christopher James Lock
Ilka Müller
David Sheppard
Mike Lipkin
David Hardick
Peter Blurton
Philip M. Leonard
Paul A. Hubbard
Daniel Todd
Christine M. Richardson
Thomas Ahrens
Manuel Baader
Doris Hafenbradl
Kate Hilyard
Roland Bürli
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Citations (30)
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