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Steven L. Wagner

University of California, San Diego

60

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6025

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Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.

2021 Journal of Experimental Medicine
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Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators

2020 Bioorganic & Medicinal Chemistry
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γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.

2020 Langmuir
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Dedifferentiation and neuronal repression define familial Alzheimer's disease.

2020 Science Advances
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Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

2020 Nature Communications
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The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer’s Disease

2020 Journal of Alzheimer's Disease
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Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates

2020 Journal of Experimental Medicine
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APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model

2019 Cell Reports
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Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model

2019 Journal of Biological Chemistry
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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons

2019 Cell Stem Cell
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Citations (108)