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Bradley Niesner
Bradley Niesner
Systems pharmacology
Enzyme replacement therapy
Biology
Pathophysiology
Olipudase alfa
5
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25
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A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat.
2020
Ruth E. Abrams
Chanchala D. Kaddi
Mengdi Tao
Randolph J. Leiser
Giulia Simoni
Federico Reali
John E. Tolsma
Paul Jasper
Zachary van Rijn
Jing Li
Bradley Niesner
Jeffrey S. Barrett
Luca Marchetti
M. Judith Peterschmitt
Karim Azer
Susana Neves‐Zaph
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Citations (5)
Catalyst Design Study of Detailed Reaction Model including Gas Diffusivity into the Washcoat
2019
Osami Yamamoto
Yuichi Matsuo
Shinichi Tosa
Tatsuya Okayama
John E. Tolsma
Zhiwei Zhang
Bradley Niesner
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Integrated quantitative systems pharmacology (QSP) model of lysosomal diseases provides an innovative computational platform to support research and therapeutic development for the sphingolipidoses
2018
Molecular Genetics and Metabolism
Chanchala Kaddi
Federico Reali
Luca Marchetti
Bradley Niesner
Silvia Parolo
Giulia Simoni
Susana Zaph
Mengdi Tao
Ruth E. Abrams
Zachary van Rijn
John P. Leonard
M. Judith Peterschmitt
Ana Cristina Puga
Kevin Mange
Jeffrey S. Barrett
Corrado Priami
Edward H. Schuchman
Karim Azer
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Citations (6)
Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology
2018
Chanchala Kaddi
Bradley Niesner
Rena Baek
Paul Jasper
John Pappas
John E. Tolsma
Jing Li
Zachary van Rijn
Mengdi Tao
Catherine Ortemann‐Renon
Rachael Easton
Sharon Tan
Ana Cristina Puga
Edward H. Schuchman
Jeffrey S. Barrett
Karim Azer
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Citations (11)
Quantitative systems pharmacology model of acid sphingomyelinase deficiency and the enzyme replacement therapy olipudase alfa is aninnovative tool for linking pathophysiology and pharmacology
2017
Molecular Genetics and Metabolism
Chanchala Kaddi
Rena Baek
Paul Jasper
Bradley Niesner
John Pappas
John E. Tolsma
Jing Li
Shayne Watson
Sharon Tan
Ana Cristina Puga
Edward H. Schuchman
Jeffrey S. Barrett
Karim Azer
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Citations (2)
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