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Heather A. Hirsch

Harvard University

20

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Abstract 4053: Genetic and molecular profiling of ICOS hi CD4 T cells demonstrates clonal expansion of Th1 effector cells following JTX-2011 treatment in subjects with solid tumors

2019 Immunology
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ICONIC: Biologic and clinical activity of first in class ICOS agonist antibody JTX-2011 +/- nivolumab (nivo) in patients (pts) with advanced cancers.

2018 Journal of Clinical Oncology
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Abstract 1678: Integrated genomics and histology based studies of triple negative breast cancer identify ICOS as potential target for therapeutic intervention

2018 Cancer Research
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Abstract 1685: Genomics based studies of gastric tumors identify ICOS as potential target for therapeutic intervention

2018 Cancer Research
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Abstract SY03-02: Preclinical assessment of JTX-2011, an agonist antibody targeting ICOS, supports evaluation in ICONIC clinical trial

2017 Cancer Research
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Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

2013 Proceedings of the National Academy of Sciences of the United States of America
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Abstract 4372: Evaluating TBK1 as a cancer therapeutic target in cancer cell lines with activated IRF3.

2013 Cancer Research
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Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types

2011 Cancer Research
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Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

2011 Proceedings of the National Academy of Sciences of the United States of America
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Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

2010 Molecular Cell
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