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Frederick Sannajust

Merck & Co.
United States Military Academy

50

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Combining an in silico pro-arrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig

2020 Journal of Pharmacological and Toxicological Methods
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Cardiovascular effects of adenosine transporter (ENT1) inhibition in various preclinical animal models

2020 Journal of Pharmacological and Toxicological Methods
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Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized Guinea pig assay

2020 Toxicology and Applied Pharmacology
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Drug‐induced Shortening of the Electromechanical Window is an Effective Biomarker for in Silico Prediction of Clinical Risk of Arrhythmias

2019 British Journal of Pharmacology
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Human-induced pluripotent stem cell-derived cardiomyocytes have limited IKs for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker:

2019
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Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites

2019 Toxicological Sciences
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Response of safety pharmacologists to challenges arising from the rapidly evolving changes in the pharmaceutical industry

2019 Journal of Pharmacological and Toxicological Methods
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HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges

2019 Journal of Pharmacological and Toxicological Methods
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Cell culture conditions affect the ability of high content imaging assay to detect drug-induced changes in cellular parameters in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

2019 Toxicology reports
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Workshop Report: FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms

2019 Circulation Research
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