Influence of testosterone on indomethacin and paracetamol induced analgesia in albino rats

1. Pain threshold for thermal stimulus after different doses of indomethacin and paracetamol was determined in male and female rats before and after three days treatment with testosterone. It was also determined 15 days after gonadectomy. 2. There was a significant reduction in analgesia induced by indomethacin as well as paracetamol after testosterone administration to rats. 3. There was a marked reduction in analgesia induced by these drugs if the rats are gonadectomised and naloxone enhanced the indomethacin and paracetamol induced analgesia.