Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres

mice with short telomeres showdecreased trimethylation of histone 3 at Lys9 (H3K9) andhistone 4 at Lys20 (H4K20) in telomeric and subtelomericchromatin as well as decreased CBX3 binding accompaniedby increased H3 and H4 acetylation at these regions.Subtelomeric DNA methylation is also decreased inconjunction with telomere shortening in Terc