12 Antioxidant and B-vitamins and Atherosclerosis

Key Points • Atherosclerosis is an interlinked inflammatory free-radical process. • Observational studies suggest that antioxidant and B-vitamins may reduce cardiovascular disease. • Randomized controlled trials have not substantiated a reduction in cardiovascular disease with antioxidant or B-vitamin supplementation. • Randomized controlled trials raise a level of concern for the safety of certain antioxidant vitamin supplementation under certain conditions. • Current data do not support the use of antioxidant or B-vitamin supplementation for the prevention or treatment of cardiovascular disease. • Consumption of fruits and vegetables high in antioxidant and B-vitamins appears to be an important component of a healthy dietary intake and lifestyle.