The primary analysis of the related factors between dyslipidemia and renal calculi risk

Objective To evaluate the relationship between various types of dyslipidemia and the risk of kidney calculi primarily. Methods 308 patients with kidney calculi who was under treatment in our hospital from January 2012 to February 2015 were chosen as calculi group, while 302 normal cases who receive physical examination in our hospital from 2012 to 2015 were chosen as control group. Data relating to case’s age, gender, body mass index (BMI), the prevalence of hypertension and diabetes mellitus, serum total triglyceride (TG), total cholesterol (TC), serum high-density lipoprotein cholesterol (HDL-C) and serum low-density lipoprotein cholesterol (LDL-C) were collected. The multi-factor Logistic regression analysis was used to explore the independent risk factors of dyslipidemia causing renal calculi. Results The median of TG, TC, HDL-C, LDL-C in calculi group were 1.285, 4.470, 1.055, 2.330 mmol/L respectively, and were 1.225, 4.690, 1.390, 2.580 mmol/L in control group respectively. Compared to the controls, the calculi group had significantly lower TG, LDL-C, and HDL-C levels. The calculi group was also more likely to have hypertriglyceridemia and low HDL-cholesterolemia compared to controls (each P=0.000). Logistic regressive analysis showed that hypertriglyceridemia [odds ratio (OR)=2.181, P=0.017] and low HDL-cholesterolemia (OR=16.214, P=0.000) were the independent risk factors for renal calculi. Conclusion Dyslipidemia may play a crucial part in the risk of renal calculi, hypertriglyceridemia and low HDL-cholesterolemia may be the independent risk factors for renal calculi. Key words: Dyslipidemia; Kidney calculi; Risk factors