Alcohol consumption and probable REM sleep behavior disorder: a community-based study (P1.128)

Objective: To systematically examine the association between alcohol intake and risk of having probable REM sleep behavior disorder (pRBD). Background: From recent epidemiological studies of potential risk factors for RBD, alcohol consumption was reported in association with higher risk of RBD or probable RBD. However, most studies to date were either relatively small or not specifically intended to evaluate the dose and type of alcohol beverage used. Studying this effect in more detail could help to understand the potential role of alcohol in the pathogenesis of different health outcomes, which are closely related to RBD. Design/Methods: The study included 11,905 participants (mean age: 47.7 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury in 2006. We determined pRBD using a validated RBD questionnaire–Hong Kong in 2012. Amounts and types of alcohol intake were collected with questionnaire. Participants were categorized into: non-drinkers, light (women: 0–0.4 servings/d; men: 0–0.9 servings/d), moderate (women: 0.5–1.0 servings/d; men: 1–2 servings/d), and heavy drinkers (women: >1 servings/d; men: >2 servings/d). To test differences in prevalence of pRBD across drinking status, we used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for demographic characteristics, smoking status, hypertension, diabetes, physical activity, body mass index, and plasma concentrations of lipids and urate. Results: Compared with non-current drinkers, current drinkers had a 23% higher risk of having pRBD (OR 1.23, 95% CI 1.07–1.59). Both moderate (adjusted OR: 1.53, 95% CI 1.01–2.30) and heavy drinkers (adjusted OR: 1.29, 95% CI 1.00–1.66) had a significantly higher risk of pRBD. There was a non-significant trend between consumption of each individual alcoholic beverages (i.e., beer, wine, or hard liquor) and higher risk of having pRBD (adjusted ORs ranged from 0.07 to 0.29). Conclusions: Alcohol consumption was associated with a higher risk of having pRBD. Study Supported by: This work was supported by the National Institute of Neurological Disorders And Stroke at the National Institutes of Health (NINDS 5R21NS087235-02 and 1R03NS093245-01A1). Disclosure: Dr. Ma has nothing to disclose. Dr. Pavlova has nothing to disclose. Dr. Li has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Sun has nothing to disclose. Dr. Huang has nothing to disclose. Dr. Wu has nothing to disclose. Dr. Gao has nothing to disclose.