166 Longitudinal diastolic myocardial functions are affected by obesity in young people: a study of color tissue doppler imaging

related with age, r=-0.713, p<0.001 and r=-0.744, p<0.001; E/E' also corre- lated with age, r=0.436, p<0.001 and r=0.569, p<0.001, respectively. Conclusion: Colour TDI derived E/E' is higher than published normal ranges obtained by PW TDI. It increases with age, and is higher in women. This should be taken in account while assessing diastolic function of heart. dysfunction. SRs was independently predicted by fasting insulin (beta =-0.30, p<0.003), UAE (beta =-0.38, p<0.0001), hs-CRP (beta =-0.26, p<0.006) and apolipoprotein B/apolipoprotein A1 (beta =-0.18, p<0.04), whereas SRe by fasting insulin (beta =-0.24, p<0.01), UAE (beta =-0.41, p<0.0001), apolipoprotein A1 (beta =0.31, p<0.001) and hs-CRP (beta =-0.22, p<0.02). Conclusions: LV dysfunction in premenopausal obese women is determined by the presence of IR and subclinical inflammation. Independent predictors of abnormalities of LV performance are fasting insulin, UAE, hs-CRP, apolipoprotein A1 and apolipoprotein B/ apolipoprotein A1. Table 1 IR+