Abstract LB-060: Detection of HER2+ tumor cells using MagSenseTM nanoparticles: safety and sensitivity

MagSense TM is an in-vivo diagnostic for the detection of primary and metastatic disease. The platform consists of tumor targeting superparamagnetic iron oxide nanoparticle (NPs) and a device capable of distinguishing the magnetic signatures of NPs that are free (e.g. flowing through the blood) from those that reach and bind their intended target (e.g., the cancer cell). Our first intended use of this technology is to test the ability of MagSense NPs labeled with an anti-HER2 antibody to detect HER2+ breast cancer in the sentinel and axillary lymph nodes of patients previously confirmed with HER2+ disease. Our preclinical data on the MagSense™-anti-HER2 platform reveal: 1) specific binding and detection of HER2 positive tumor cells in-vitro (5000 cells); 2) specific detection of HER2 positive tumors in-vivo; 3) binding and amplitude of the magnetic signal is proportional to the level of HER2 expression in-vitro and in-vivo; and 4) the nanoconstruct remains stable in circulation. Based on these supportive preclinical data, the MagSense Anti-HER2 NPs are being produced under cGMP along with an RD 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr LB-060.