IDDF2019-ABS-0086 Clinical profile of patients with hepatocellular carcinoma at st. luke’s medical center and cardinal santos medical center from 2003-july 2018

Background In the Philippines, data is limited on the characteristics of patients with hepatocellular carcinoma (HCC). Recent studies from other neighboring Asian countries suggests a change in trend in the epidemiology of HCC. This study aims to update the data, describe the etiology and clinical profile of patients with HCC at 2 tertiary referral centers in the Philippines. Methods This is a two-center retrospective, descriptive study of all adult patients with hepatocellular carcinoma at St. Luke’s Medical Center, Quezon City (SLMC-QC) and Cardinal Santos Medical Center (CSMC). Clinical profile data, specifically patient‘s age, gender, presence or absence of liver cirrhosis, Child’s Pugh score, and registered etiology of HCC (HBV, HCV, alcoholic liver disease, nonalcoholic fatty liver disease, others) was obtained and recorded in a Microsoft Excel. Data were analyzed using descriptive statistics. Results A total of 1260 subjects were included in this study. Patients were predominantly male (76.1%) with a mean age of 63. The majority (83.3%) developed HCC under a background of liver cirrhosis, with baseline liver function under Child-Pugh B at 51.8%, followed by Child’s A (23%) and Child’s C (17.6%). Hepatitis B (44.3%) is the most common etiology, followed by NAFLD (16%). Hepatitis B was also the most predominant etiology for HCC in noncirrhotic HCC patients. Conclusions Patients with HCC from both our centers are mostly males, with a mean age of 63. Majority developed HCC on a background of liver cirrhosis, with hepatitis B being the most common etiology followed by NAFLD.