Enfermedad Celiaca en pacientes pediátricos con Diábetes Mellitus Tipo 1

Objetivo: Determinar cuales ninos con Diabetes Mellitus tipo 1 cumplen con los requisitos para el diagnostico de Enfermedad Celiaca. Materiales y metodos. 118 ninos provenientes del Servicio Endocrinologia del Hospital "JM de los Rios" entre 2 a 18 anos se interrogaron en busca de sintomas y se determino antitransglutaminasa tisular, endoscopia digestiva y biopsias seriadas a los que presentaron dicho anticuerpo positivo. Resultados: 118 pacientes 61 ninas, edad media 12,06 μ 4,1 anos, rango de 3,4 a 18 anos. No se evidencio signos o sintomas que correspondieran a Enfermedad Celiaca, 4/118 resultaron positivos para antitransglutaminasa, 3/4 se les realizo endoscopias y 2 presentaron histologia compatibles con Enfermedad Celiaca (Marsh 3a y 3b) Los pacientes diabeticos tipo 1 pueden presentar Enfermedad Celiaca asintomatica como comorbilidad, pudiendo ser silente o latente. Esta poblacion en riesgo debe investigarse de manera acuciosa en pesquisa de esta entidad. Conclusion: Se reportan 2 casos nuevos de Enfermedad Celiaca asintomatica en ninos con Diabetes, que corresponde al 1,69% similar a lo reportado a nivel mundial. Sugerimos la realizacion de estudios de despistaje a los grupos susceptibles en este pais de presentar esta entidad, y estudios poblacionales para conocer la prevalencia de la Enfermedad Celiaca en Venezuela. Objective: To determine which children with type 1 diabetes fulfilled the requirements for the diagnosis of Celiac disease. Methods: 118 pediatric patients from the Endocrinology service of the Hospital "JM de los Rios" having type I diabetes. We carried out an interrogation, searching the presence of signs or symptoms, and screening for the antibody tissue transglutaminase and endoscopy taking several small bowel biopsies, to those displaying positive tests. Results: 118 patients, there were 61 girls, mean age 12,06 μ 4,1 years and a range from 3,4 to 18 years. At time of the study we did not find signs or symptoms that corresponded with Celiac disease, 4/118 were positive for the transglutaminase antibody test and 3 / 4 patients underwent endoscopies, and 2 had definite biopsy (Marsh score 3a and 3b) evidence of celiac disease. Diabetic patients type 1 can have asintomatic celiac Disease silent or latent, for that reason these children should be screened for celiac Disease. Conclusion: We found 2 new cases of asintomatic celiac disease in type 1 diabetic children (1,69%) , similar to those reported at world level. We suggest screening antibodies to susceptibles groups of presenting this disease in this country and screening for celiac disease in our population to know the prevalence of this disorder in Venezuela.