Adriamycin cardiotoxicity in children. Case reports, literature review, and risk factors

Two children with Wilms' tomor and prior thoracic radiation developed congestive heart failure at cumulative adriamycin doses of 350 mg/m2 and 400 mg/m2. Details of these two cases and a summary of previously reported adriamycin cardiotoxicity in children are presented. Dose recommendations and predictive tests are discussed.