937 Survivin Inhibitor YM155 Induces Apoptosis and Inhibits Tumor Growth of Human Gastric Carcinoma

G A A b st ra ct s size (from 6,4±0,4 mm to 2,3 ±0,1 mm, p,0,01), in comparison with untreated mice. In contrast, tumor density and growth was enhanced by systemic delivery of the lymphangiogenic factor VEGF-C, which in turn increased lymphangiogenesis within the same regions. HILEC isolated from colorectal cancer biopsies showed increased growth rate and capacity to undergo tubulogenesis in vitro (38 ±1,5 number of tumoral tubes vs 14 ±0,5 number of NL tubes, p,0,01) compared to healthy control tissues. Conclusion: Our findings demonstrate that VEGFC/VEGFR-3-dependent lymphangiogenesis plays a role not only in metastasis dissemination, but also in colitis-associated tumor growth. Therefore, the lymphatic vasculature may be a promising target for the prevention and the treatment of IBD-related Colorectal Cancer.