Safety and effectiveness of different treatment regimes with tranexamic acid in elective cardiopulmonary bypass patients

Although tranexamic acid (TA) has been effective in reducing bleeding after cardiac surgery, the TA dosing scheme varies extremely and the agent is highly overdosed in most relevant trials. In a dose-dependent fashion, TA is associated with an increase of adverse events, particularly the observation of seizures. In this study we aimed to assess the safety and effectiveness of different treatment regimes of TA in cardiopulmonary bypass (CPB) patients.