Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

Dale J. Lange,Mona Shahbazi,Vincenzo Silani,Albert C. Ludolph,Jochen H. Weishaupt,Senda Ajroud-Driss,Kara G. Fields,Rahul Remanan,Stanley H. Appel,Claudia Morelli,Alberto Doretti,Luca Maderna,Stefano Messina,Ulrike Weiland,Stefan L. Marklund,Peter M. Andersen

Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

2017

Dale J. Lange
Mona Shahbazi
Vincenzo Silani
Albert C. Ludolph
Jochen H. Weishaupt
Senda Ajroud-Driss
Kara G. Fields
Rahul Remanan
Stanley H. Appel
Claudia Morelli
Alberto Doretti
Luca Maderna
Stefano Messina
Ulrike Weiland
Stefan L. Marklund
Peter M. Andersen

Objective: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1-transgenic animal models. Pyrimethamine produces dose-dependent SOD1 reduction in cell culture systems. A previous p ...

Keywords:

Superoxide dismutase
Anesthesia
Diabetes mellitus
Immunology
Amyotrophic lateral sclerosis
SOD1
Pyrimethamine
Cu-Zn Superoxide Dismutase
Cell culture
Medicine
Pharmacology
Cerebrospinal fluid
zn superoxide dismutase
treatment outcome
Mutation

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations