Resting heart rate in subjects with carbohydrate disorders

UNLABELLED: Large epidemiological studies conducted during last 25 years confirmed the importance of resting heart rate as an independent risk factor for total and cardiovascular mortality in females and males, both in overall population and in subjects with cardiovascular diseases such as arterial hypertension, myocardial infarction, coronary heart disease, heart failure or left ventricular dysfunction. The aim of the study was to evaluate the resting heart rate (HR) in subjects with carbohydrate disorders. MATERIAL AND METHODS: The study comprised 112 subjects with carbohydrate disorders (54 females and 58 males), aged 30-78 (57.4 +/- 9.6) years. Carbohydrate disorders were diagnosed according to the Polish Diabetes Association criteria from 2007 (group I). 56 subjects had impaired fasting glucose (IFG), 36 - impaired glucose tolerance (IGT) and 20 - type 2 diabetes. Comparative group comprised 30 subjects without cardiovascular diseases and carbohydrate disorders (15 females and 15 males), aged 29-64 (52.7 +/- 8.8) years (group II). The fasting serum glucose level was evaluated using an enzymatic method, Kone Pro biochemical analyzer and bioMerieux Glucose RTU kit. In subjects with fasting glucose level > or = 100 mg/dl, an oral glucose tolerance test (OGTT) was performed. Additionally, in all subjects resting heart rate (HR) was measured, after 10-minute rest, at a room temperature of about 20 degrees C. The measurements were made threefold, every 5 minutes and mean value was assessed. RESULTS: In subjects with carbohydrate disorders HR was significantly higher than in comparative group (82.79 +/- 12.1 vs 69.9 +/- 9.56/min; p or = 72.5/min is an independent risk factor for carbohydrate disorders. CONCLUSIONS: Resting heart rate > or = 72.5/min is an independent risk factor for carbohydrate disorders and increases its risk more than ninefold.