1424. Examining the Relationship Between Vancomycin Area Under the Concentration–Time Curve and Serum Trough Levels in Adults with Presumed or Documented Staphylococcal Infections

Background Recent studies evaluating area under the concentration–time curve (AUC)-guided vancomycin dosing have reported reduced drug exposure and nephrotoxicity as compared with traditional trough-guided (target 15–20 mg/L) dosing for invasive infections, but studies exploring the relationship between vancomycin trough concentration and AUC remain limited.