Research and treatment progress on post-transplantation diabetes mellitus caused by tacrolimus

Post-transplantation diabetes mellitus (PTDM) is one of the most common and severe complications after solid organ transplantation. PTDM is a high risk factor for graft dysfunction, infection, cardiovascular complications and acute graft rejection, which affected survival rate and the quality of life of recipients. Tacrolimus is a powerful kind of immunosuppressant which is widely used on organ recipients. However, tacrolimus is more diabetogenic than other kind of immunosuppressant. Here we summarized the research and treatment progress of tacrolimus on PTDM. Key words: Tacrolimus; Immunosuppressant; Post-transplantation diabetes mellitus