Vasodilator therapy of pulmonary hypertension in the crst syndrome

TWO patients with the CRST syndrome and pulmonary hypertension are described. They were treated with hydralazine given orally in a dosage of 200 mgs daily. One patient improved subjectively and had a better exercise capacity but the signs of pulmonary hypertension and tricuspid regurgitation persisted. The other patient has shown a marked clinical improvement and a significant reduction of the pulmonary hypertension has been demonstrated on repeat cardiac catheterisation.