Two-year outcomes of therapeutic hypothermia in perinatal hypoxic-ischaemic encephalopathy cases at Chiang Mai University Hospital.

This study aimed to report long-term outcomes of 23 infants with perinatal hypoxic–ischaemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH) at Chiang Mai University Hospital between February 2013 and February 2015. Informed consents were obtained at the follow-up clinic. The Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) was employed by developmental–behavioural paediatricians; visual impairment was evaluated by ophthalmologists and otoacoustic emissions (OAE)/auditory brainstem response (ABR) was used to identify any hearing impairment. Severe disability was defined by any of the following: Bayley-III (any domains)<70, Gross Motor Function Classification System≥3, severe visual impairment and profound hearing impairment. The results demonstrated that death, severe disabilities, and combined death and severe disabilities were 36.4%, 23.5% and 58.8%, respectively (table 1 and figure 1). If the analysis included lost to follow-up and non-participating patients, those outcomes would be …