HindIII Polymorphism in the Lipoprotein Lipase Gene and Hypertensive Intracerebral Hemorrhage in the Chinese Han Population

Background To investigate the relationship between the Hin dIII polymorphism and hypertensive intracerebral hemorrhage (HIH) and lipid metabolism. Methods A polymerase chain reaction–restriction fragment length polymorphism assay and the chain termination DNA sequencing method were used to determine the Hin dIII genotypes of 267 subjects, which included 120 cerebral hemorrhagic patients and 147 controls. The fasting levels of lipids and glucose in the plasma were used to measure the effect of genotype on HIH risk factors. Results The frequency of the T allele of the Hin dIII polymorphism in the HIH group was 90.8%. The frequency of the G allele was 9.2%. In the control group, the frequencies were 82.3% T and 17.7% G, which indicated that the proportion of the G allele in the HIH patient group was significantly lower than in the control group ( P GG + GT genotypes in HIH patients ( P P P Hin dIII G allele was negatively correlated with the incidence of HIH (odds ratio = .417, 95% confidence interval: .193-.901). Conclusions The Hind III G allele may be a protective factor against the development of HIH among the Han Chinese population.