Effect of restoration of 25OHD3 status in prolonged critical illness on serum innate immunity parameters LL-37 and sCD163

We previously observed that critically ill patients are vitD deficient. This status cannot be restored by increasing the normally recommended intravenous vitD dose. The antimicrobial peptide LL-37 is expressed in macrophages upon stimulation by 25OHD3. sCD163 is a soluble pattern-recognition receptor, which is a marker of macrophage activation and a predictor of mortality in SIRS. The aim of this study is to unravel the impact of 25OHD3 deficiency and normalization on innate immunity parameters - CRP, LL-37 and sCD163 - in critical illness.