Link controversies between COVID-19 and diabetes mellitus type ii in Paraiba

Introduction: The state of art says that the Diabetes Mellitus (DM) type II is a risk factor for 2019 coronavirus infection But, nowadays, we find some evidence that does not agree with this hypothesis Objectives: We aim to evaluate the correlation between DM, biomarkers of mortality (D-dimer, PCR, and ferritin), and COVID-19 outcomes Methods: We conducted a cohort, observational, longitudinal, and prospective study between June 1 to August 15, 2020, in Joao Pessoa city We collected demographic data, medical history, and hospital course from 200 patients Then, we used Spearman's correlation and multivariate logistic regression to measure correlations Results: In our sample, 88 (44%) patients had diabetes diagnosis Further, 121 (61 5%) had glycated hemoglobin over 6 5% during hospitalization In the multivariate logistic regression analysis, the previous diagnosis of DM showed no significant difference (adjusted OR: 1 833;95% CI: 0 82-4 19, p = 0 202) Glycated hemoglobin had a median of 8 07% in surviving patients and 8 72% in non-surviving patients And there was no significant difference between them (P = 0 39) Also, in univariate logistic regression, decompensated DM (HG > 7 5%) showed no significant difference to mortality (adjusted OR: 1 317;95% CI: 0 588 - 3 017;P = 0 56) or disease severity outcome (OR adjusted: 1 157;95% CI: 0 604 - 2 226;P = 0 70) In Pearson's correlation, glycated hemoglobin showed a positive correlation with the PCR (R = 0 164, P = 0 033) and with the D-dimer (R = - 0 158, P = 0 032);and negative with the TGO enzymes (R = - 0 182, P = 0 013), TGP (R = -0 159, P = 0 031) and with the DHL (R = -0 168, P = 0 024) Conclusion: The diagnosis of type 2 diabetes mellitus, previously recognized or not, was quite prevalent in the studied population We did not found the DM as a significant risk factor for COVID-19 outcomes