The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly
2009
Objective: The aim of the study was to evaluate the impact of the genomic deletion of exon 3 of the GH receptor (d3GHR) on long-term clinical outcome of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly. Design: We conducted a cross-sectional study. Methods: The presence of the d3GHR polymorphism was assessed in 86 acromegalic patients with long-term disease control and related to anthropometric parameters, cardiovascular risk factors, osteoarthritis, bone mineral density, colonic polyps and diverticulae, and dolichocolon. Results: Fifty-one patients had two wild-type alleles (59%), whereas 29 patients (34%) had one allele and six patients (7%) had two alleles encoding for the d3GHR isoform. Carriers of the d3GHR isoform showed increased prevalence of osteoarthritis, especially of the hip [adjusted odds ratio (OR), 5.2; 95% confidence interval (CI), 3.2–7.1], of adenomatous polyps (adjusted OR, 4.1; 95% CI, 2.4–5.6), and dolichocolon (adjusted OR, 3.2; 95% CI, 1....
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