Effects of age on coronary autoregulation and reactive hyperemic response in isolated, nonworking, blood-perfused rat hearts

We examined the effects of age on coronary autoregulation (autoregulatory gain) and reactive hyperemic response (peak flow/myocardial tissue weight ratio, flow reserve, peak/resting flow ratio, repayment/debt flow ratio, and the duration of hyperemia) after brief ischemia in developmental (3 mo of age), young-adult (8 mo), and old rats (19 mo)