Results of a Randomized Phase II Trial of Intense Androgen Deprivation Therapy Prior to Radical Prostatectomy in Men with High-Risk Localized Prostate Cancer

Rana R. McKay,Wanling Xie,Huihui Ye,Fiona M. Fennessy,Zhenwei Zhang,Rosina T. Lis,Carla Calagua,Dana E. Rathkopf,Vincent P. Laudone,Glenn J. Bubley,David J. Einstein,Peter Chang,Andrew A. Wagner,J. Kellogg Parsons,Mark A. Preston,Kerry L. Kilbridge,Steven L. Chang,Atish D. Choudhury,Mark Pomerantz,Quoc-Dien Trinh,Adam S. Kibel,Mary-Ellen Taplin

Results of a Randomized Phase II Trial of Intense Androgen Deprivation Therapy Prior to Radical Prostatectomy in Men with High-Risk Localized Prostate Cancer

2021

Purpose:This multicenter randomized phase 2 trial investigates the impact of intense androgen deprivation on radical prostatectomy (RP) pathologic response and radiographic and tissue biomarkers in...

Keywords:

Urology
Apalutamide
Prostate cancer
Abiraterone
tissue biomarkers
Androgen
Androgen deprivation therapy
Prostatectomy
Medicine
Pathologic Response

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