Response by Kempny et al to Letter Regarding Article, “Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study”

We thank Ferrero et al for their interest in our recent publication in Circulation .1 We aimed in this study to assess mortality and management strategies in contemporary patients with Eisenmenger syndrome (ES). Although the incidence and prevalence of ES seem to decrease in developed countries, it remains worldwide a common complication of congenital heart disease.2,3 There has been considerable progress in the management of ES over the past 1 to 2 decades. Routine phlebotomies, for example, often resulting in iron deficiency, microcytosis, and inappropriately low hemoglobin levels, have been abandoned.4 There is increased awareness of the risks associated with even minor surgery and pregnancy; as a result, fewer patients with ES die of periprocedural …