Homocysteine and Vascular Disease: The European Concerted Action Project

Aterosclerotic cardiovascular disease, notably coronary heart disease, remains the major cause of death in developed countries [1]. A high-fat diet, hypertension, and smoking are regarded as causal factors [2], and changes in these factors appear to contribute to coronary heart disease mortality trends [3]. Nevertheless, these factors remain incomplete predictors of both the occurrence of and changes in cardiovascular mortality.