The study on the correlation between hypoxia inducible factor induced E-cad collagen transformation in bladder outlet obstruction and detrusor function

Objective To investigate the correlation between hypoxia inducible factor (HIF) induced collagen transformation of epithelial cadherin (E-cad) and detrusor function. Methods From May 2014 to October 2017, 50 patients with overactive bladder(OAB) caused by bladder outlet obstruction(BOO)undergoing urological surgery were selected as observation group, and 50 cases of bladder outlet obstruction without detrusor instability were selected as control group at the same time. The maximal uroflow rate and detrusor instability(DI) were performed in the two groups by UDS-94-BT urodynamic analyzer and detrusor pressure with maximal uroflow rate. Tissue samples were taken from the lesion and the expressions of HIF and E-cad in the two groups were measured by immunohistochemical method. SPSS Pearson correlation analysis was used to analyze the correlation between E-cad collagen conversion and detrusor function induced by bladder outlet obstruction HIF. Results The positive rate of HIF in the observation group was higher than that in the control group (P<0.05), and the expression of E-cad collagen in the observation group was lower than that in the control group (P<0.05). The maximal uroflow rate and maximal uroflow velocity in the observation group were lower than those in the control group (P<0.05). DI rate in the observation group was higher than that in the control group (P<0.05). SPSS Pearson correlation analysis showed that the positive rates of HIF, E-cad collagen in the observation group and the maximum uroflow rate, DI and maximum uroflow rate. Urinary muscle pressure was negatively correlated (P<0.05). Conclusions The expression of HIF and E-cad is abnormal in the patients with bladder outlet obstruction, and is significantly related to detrusor function. It provides a new idea for the study of the abnormal mechanism of detrusor dysfunction and the treatment of the disease. Key words: Urinary Bladder Neck Obstruction; Hypoxia-Inducible Factor 1; Urinary Bladder, Overactive; Cadherins