Enhanced antibacterial activity of roxithromycin loaded pegylated poly lactide-co-glycolide nanoparticles
2012
Background and the purpose of the study
The purpose of this study was to prepare pegylated poly lactide-co-glycolide (PEG-PLGA) nanoparticles (NPs) loaded with roxithromycin (RXN) with appropriate physicochemical properties and antibacterial activity. Roxithromycin, a semi-synthetic derivative of erythromycin, is more stable than erythromycin under acidic conditions and exhibits improved clinical effects.
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